SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF TRUNCATED ACRIDONE - STRUCTURE-ACTIVITY RELATIONSHIP STUDIES OF CYTOTOXIC 5-HYDROXY-4-QUINOLONE

Authors
CHUN MW OLMSTEAD KK CHOI YS LEE CO LEE CK KIM JH LEE JW
Citation
Mw. Chun et al., SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF TRUNCATED ACRIDONE - STRUCTURE-ACTIVITY RELATIONSHIP STUDIES OF CYTOTOXIC 5-HYDROXY-4-QUINOLONE, Bioorganic & medicinal chemistry letters, 7(7), 1997, pp. 789-792
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
7
Year of publication
1997
Pages
789 - 792
Database
ISI
SICI code
0960-894X(1997)7:7<789:SABOTA>2.0.ZU;2-9
Abstract
A series of 5-hydroxy-4-quinolone (3) and 5-methoxy-4-quinolone (4) de rivatives were synthesized as truncated acridone analogues and evaluat ed for antitumor and antiherpes activities. Among them 5-hydroxy-8-met hoxy-quinolone showed potent antitumor activity (IC50 = 17.7 mu M for HL60) which was greater than that of acronycine. (C) 1997 Elsevier Sci ence Ltd.