DICARBOXYLIC-ACID INHIBITORS OF PHOSPHOLIPASE A(2)

Authors
SPRINGER DM LUH BY DANDREA SV BRONSON JJ MANSURI MM BURKE JR GREGOR KR STANLEY PL TRAMPOSCH KM
Citation
Dm. Springer et al., DICARBOXYLIC-ACID INHIBITORS OF PHOSPHOLIPASE A(2), Bioorganic & medicinal chemistry letters, 7(7), 1997, pp. 793-798
Citations number
30
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
7
Year of publication
1997
Pages
793 - 798
Database
ISI
SICI code
0960-894X(1997)7:7<793:DIOPA>2.0.ZU;2-W
Abstract
Ten diacids were synthesized via a simple regio- and stereoselective a ldol reaction. All of these compounds were good to excellent inhibitor s of 14 kDa human platelet PLA(2), and many of these derivatives displ ayed activity in a phorbol-ester induced mouse ear edema assay. One of the new compounds reported here was selected for further development as a potential antipsoriasis agent. (C) 1997 Elsevier Science Ltd.