[Meso- and rac-1,2-bis(4-fluorophenyl)ethylenediamine]chloro[sulfinyl-bis(methane)-S]platinum(II) chloride new water soluble platinum complexes with high anti-breast cancer activities

Authors
Gust, R Heinrich, H Krauser, R Schonenberger, H
Citation
R. Gust et al., [Meso- and rac-1,2-bis(4-fluorophenyl)ethylenediamine]chloro[sulfinyl-bis(methane)-S]platinum(II) chloride new water soluble platinum complexes with high anti-breast cancer activities, INORG CHIM, 285(2), 1999, pp. 184-189
Citations number
16
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
INORGANICA CHIMICA ACTA
ISSN journal
00201693 → ACNP
Volume
285
Issue
2
Year of publication
1999
Pages
184 - 189
Database
ISI
SICI code
0020-1693(19990215)285:2<184:[AR>2.0.ZU;2-5
Abstract
The synthesis, the physiochemical and the breast cancer inhibiting properti es of [meso- and rac-1,2-bis(4-fluorophenyl)ethylenediamine]chloro[sulfinyl bis(methane)-S]platinum(II) chlorides(meso- and rac-4F-PtCl(DMSO)) are desc ribed, Rac-4F-PtCl(DMSO) surpasses the standard carboplatin in its effect o n the human MCF-7 breast cancer cell line and is more resistant than its: d ichloroplatinum(II) analogue rac-4F-PtCl2 against attack of nucleophiles, a prerequisite for sufficient stability in physiological environments and co nsequently for marked antitumor activity in vivo. [GRAPHICS] (C) 1999 Elsevier Science S.A. All rights reserved.