LIBRARIES OF ANGIOTENSIN-CONVERTING ENZYME-INHIBITORS - SOLID-PHASE SYNTHESIS AND AFFINITY SELECTION

Authors
BLACKBURN C PINGALI A KEHOE T HERMAN LW WANG HQ KATES SA
Citation
C. Blackburn et al., LIBRARIES OF ANGIOTENSIN-CONVERTING ENZYME-INHIBITORS - SOLID-PHASE SYNTHESIS AND AFFINITY SELECTION, Bioorganic & medicinal chemistry letters, 7(7), 1997, pp. 823-826
Citations number
33
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
7
Year of publication
1997
Pages
823 - 826
Database
ISI
SICI code
0960-894X(1997)7:7<823:LOAE-S>2.0.ZU;2-4
Abstract
Libraries of ACE inhibitors were prepared by solid-phase methods invol ving reductive alkylation of resin-bound dipeptides, H-X-Pro-DHPP-PEG- PS or H-X-X-PAL-PEG-PS. Affinity selection of the library components i dentified hydrophilic N-alkylated dipeptides as potential inhibitors. (C) 1997 Elsevier Science Ltd.