ANTINEOPLASTIC AGENTS .370. ISOLATION AND STRUCTURE OF DOLASTATIN-18

Authors
PETTIT GR XU JP WILLIAMS MD HOGAN F SCHMIDT JM CERNY RL
Citation
Gr. Pettit et al., ANTINEOPLASTIC AGENTS .370. ISOLATION AND STRUCTURE OF DOLASTATIN-18, Bioorganic & medicinal chemistry letters, 7(7), 1997, pp. 827-832
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
7
Year of publication
1997
Pages
827 - 832
Database
ISI
SICI code
0960-894X(1997)7:7<827:AA.IAS>2.0.ZU;2-4
Abstract
Bioassay-guided separation of cancer cell growth inhibitory fractions derived from the sea hare Dolabella auricularia obtained in Papua New Guinea led to isolation (1.51 x 10(-7)% yield) of the new thiazole-con taining peptide, dolastatin 18 (4). Structural determination was compl eted by employment of results from high-field (500 MHz) 2-D NMR experi ments and tandem MS/MS mass spectral sequence analyses. Dolastatin 18 (4) was found to inhibit a selection of cancer cell lines among which GI(50) 0.39 mu g/mL was found for the nonsmall cell lung cancer NCI-H4 60. (C) 1997 Elsevier Science Ltd.