THE PRO-OLIGONUCLEOTIDE APPROACH .5. INFLUENCE OF THE PHOSPHORUS ATOMENVIRONMENT ON THE HYDROLYSIS OF ENZYMOLABILE DINUCLEOSIDE PHOSPHOTRIESTERS

Authors
MIGNET N MORVAN F RAYNER B IMBACH JL
Citation
N. Mignet et al., THE PRO-OLIGONUCLEOTIDE APPROACH .5. INFLUENCE OF THE PHOSPHORUS ATOMENVIRONMENT ON THE HYDROLYSIS OF ENZYMOLABILE DINUCLEOSIDE PHOSPHOTRIESTERS, Bioorganic & medicinal chemistry letters, 7(7), 1997, pp. 851-854
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
7
Year of publication
1997
Pages
851 - 854
Database
ISI
SICI code
0960-894X(1997)7:7<851:TPA.IO>2.0.ZU;2-O
Abstract
Six dithymidine phosphotriester analogs bearing an enzymolabile phosph ate proctecting group were synthesized in order to select the most app ropriate model for the prooligonucleotide approach. Series (1) under b ar and (3) under bar were chosen on the basis of their stability in cu lture medium and their capacity, when incubated in total cell extract, to deliver selectively dithymidine phosphodiester and phosphorothioat e diester respectively. (C) 1997 Elsevier Science Ltd.