D-dimer assay predicts mortality in critically ill patients without disseminated intravascular coagulation or venous thromboembolic disease

Objective: To determine if D-dimer predicts outcomes in critically ill pati ents. Design: Observational, cohort study. Setting: Medical intensive care unit (MICU) of a tertiary care hospital. Pa tients and participants: Seventy-four patients consecutively admitted to th e MICU. Interventions: D-dimer was measured by latex agglutination within 12 h of a dmission to the MICU. Measurements and results: Of the study population, 43.2% had positive D-dim ers. The in-hospital mortality rate in D-dimer positive patients was 28.1% as compared to 7.1% in D-dimer negative subjects (p = 0.024). D-dimer posit ive patients had significantly greater frequencies of venous thromboses (21 .9% vs 4.8%, p = 0.035). Conclusions: The D-dimer assay identifies patients at increased risk for mo rtality and may be a more sensitive test to determine the presence of under lying microvascular pathology in critically ill patients. A positive D-dime r at admission to the MICU is associated with an increased risk for the lat er development of a venous thromboembolic event (VTE).