DIHYDROXYPYRROLIDINES C-LINKED TO GALACTOSE - TOTAL SYNTHESIS OF A SPECIFIC INHIBITOR OF ALPHA-MANNOSIDASES

Authors
KRAEHENBUEHL K PICASSO S VOGEL P
Citation
K. Kraehenbuehl et al., DIHYDROXYPYRROLIDINES C-LINKED TO GALACTOSE - TOTAL SYNTHESIS OF A SPECIFIC INHIBITOR OF ALPHA-MANNOSIDASES, Bioorganic & medicinal chemistry letters, 7(7), 1997, pp. 893-896
Citations number
39
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
7
Year of publication
1997
Pages
893 - 896
Database
ISI
SICI code
0960-894X(1997)7:7<893:DCTG-T>2.0.ZU;2-#
Abstract
New disaccharide mimics connecting 4-amino-4-deoxyerythrofuranose at C (1) to position C(3) of galactose through a CH(OH) link have been prep ared as racemates and tested toward 25 commercially available glycohyd rolases. One of them (2) is a moderate but specific (43% of inhibition at 1 mM) inhibitor of jack bean alpha-mannosidase. (C) 1997 Elsevier Science Ltd.