A NOVEL SERIES OF MATRIX METALLOPROTEINASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISORDERS

Citation
Ad. Baxter et al., A NOVEL SERIES OF MATRIX METALLOPROTEINASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISORDERS, Bioorganic & medicinal chemistry letters, 7(7), 1997, pp. 897-902
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
ISSN journal
0960894X
Volume
7
Issue
7
Year of publication
1997
Pages
897 - 902
Database
ISI
SICI code
0960-894X(1997)7:7<897:ANSOMM>2.0.ZU;2-E
Abstract
The preparation of a novel series of matrix metalloproteinase inhibito rs is described, based on the use of a mercaptoacyl zinc binding moiet y. The compounds have been tested in a model of rheumatoid arthritis a nd show good oral activity. (C) 1997 Elsevier Science Ltd.