Non-coding plasmid DNA induces IFN-gamma in vivo and suppresses autoimmuneencephalomyelitis

Authors
Boccaccio, GL Mor, F Steinman, L
Citation
Gl. Boccaccio et al., Non-coding plasmid DNA induces IFN-gamma in vivo and suppresses autoimmuneencephalomyelitis, INT IMMUNOL, 11(2), 1999, pp. 289-296
Citations number
34
Categorie Soggetti
Immunology
Journal title
INTERNATIONAL IMMUNOLOGY
ISSN journal
09538178 → ACNP
Volume
11
Issue
2
Year of publication
1999
Pages
289 - 296
Database
ISI
SICI code
0953-8178(199902)11:2<289:NPDIII>2.0.ZU;2-T
Abstract
Regulatory sequences used in plasmids for naked DNA vaccination can modulat e cytokine production in vivo. We demonstrate here that injection of plasmi d DNA can suppress the prototypic T cell-mediated autoimmune disease, exper imental autoimmune encephalomyelitis, by inducing IFN-gamma.