SYNTHESIS AND BIOLOGICAL EVALUATION OF 1-ALPHA-HYDROXY-25(R AND S)-25,26-EPOXY-23-YNE VITAMIN-D-3 AND OF 1A,25(R AND S),26-TRIHYDROXY-23-YNE VITAMIN-D-3

Authors
WU YS ZHAO XY DECLERCQ P VANDEWALLE M BOUILLON R VERSTUYF A
Citation
Ys. Wu et al., SYNTHESIS AND BIOLOGICAL EVALUATION OF 1-ALPHA-HYDROXY-25(R AND S)-25,26-EPOXY-23-YNE VITAMIN-D-3 AND OF 1A,25(R AND S),26-TRIHYDROXY-23-YNE VITAMIN-D-3, Bioorganic & medicinal chemistry letters, 7(7), 1997, pp. 929-932
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
7
Year of publication
1997
Pages
929 - 932
Database
ISI
SICI code
0960-894X(1997)7:7<929:SABEO1>2.0.ZU;2-D
Abstract
The synthesis of both 1 alpha-hydroxy-25(R and S)-25,26-epoxy-23-yne v itamin D-3 and of both 1 alpha,2S(R and S),26-trihydroxy-23-yne vitami n D-3 is described. Biological evaluation includes the study of calcem ic effect, receptor binding and cell differentiation. (C) 1997 Publish ed by Elsevier Science Ltd.