SEARCH FOR SURROGATES - A STUDY OF ENDOTHELIN RECEPTOR ANTAGONIST STRUCTURE-ACTIVITY-RELATIONSHIPS

Authors
RAJU B OKUN I STAVROS F CHAN MF
Citation
B. Raju et al., SEARCH FOR SURROGATES - A STUDY OF ENDOTHELIN RECEPTOR ANTAGONIST STRUCTURE-ACTIVITY-RELATIONSHIPS, Bioorganic & medicinal chemistry letters, 7(7), 1997, pp. 933-938
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
7
Year of publication
1997
Pages
933 - 938
Database
ISI
SICI code
0960-894X(1997)7:7<933:SFS-AS>2.0.ZU;2-#
Abstract
The aryloxymethylene group was used as a replacement for an ester or a mide bond present in a series of ETA selective endothelin antagonists. The effect of such replacement on the binding affinity is described. (C) 1997 Elsevier Science Ltd.