S. Kawanishi et al., DNA damage induced by Salmonella test-negative carcinogens through the formation of oxygen and nitrogen-derived reactive species (Review), INT J MOL M, 3(2), 1999, pp. 169-174
High levels of active oxygen species generated by carcinogenic chemicals ca
n cause DNA damage, which may lead to carcinogenesis. We have investigated
the characteristics and mechanisms of DNA damage induced by some carcinogen
s. Here we show our experimental results and propose the possible mechanism
s of DNA damage through a) NADH-dependent and b) manganese-dependent format
ion of reactive oxygen species. We also discuss the mechanism of c) DNA dam
age induced by nitric oxide and peroxynitrite.