DNA damage induced by Salmonella test-negative carcinogens through the formation of oxygen and nitrogen-derived reactive species (Review)

Authors
Kawanishi, S Hiraku, Y Inoue, S
Citation
S. Kawanishi et al., DNA damage induced by Salmonella test-negative carcinogens through the formation of oxygen and nitrogen-derived reactive species (Review), INT J MOL M, 3(2), 1999, pp. 169-174
Citations number
50
Categorie Soggetti
Medical Research General Topics
Journal title
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
ISSN journal
11073756 → ACNP
Volume
3
Issue
2
Year of publication
1999
Pages
169 - 174
Database
ISI
SICI code
1107-3756(199902)3:2<169:DDIBST>2.0.ZU;2-4
Abstract
High levels of active oxygen species generated by carcinogenic chemicals ca n cause DNA damage, which may lead to carcinogenesis. We have investigated the characteristics and mechanisms of DNA damage induced by some carcinogen s. Here we show our experimental results and propose the possible mechanism s of DNA damage through a) NADH-dependent and b) manganese-dependent format ion of reactive oxygen species. We also discuss the mechanism of c) DNA dam age induced by nitric oxide and peroxynitrite.