Formulation and evaluation of controlled release Eudragit buccal patches

Citation
Cf. Wong et al., Formulation and evaluation of controlled release Eudragit buccal patches, INT J PHARM, 178(1), 1999, pp. 11-22
Citations number
28
Categorie Soggetti
Pharmacology & Toxicology
Journal title
INTERNATIONAL JOURNAL OF PHARMACEUTICS
ISSN journal
03785173 → ACNP
Volume
178
Issue
1
Year of publication
1999
Pages
11 - 22
Database
ISI
SICI code
0378-5173(19990201)178:1<11:FAEOCR>2.0.ZU;2-D
Abstract
Controlled release buccal patches were fabricated using Eudragit NE40D and studied. Various bioadhesive polymers, namely hydroxypropylmethyl cellulose , sodium carboxymethyl cellulose and Carbopol of different grades, were inc orporated into the patches, to modify their bioadhesive properties as well as the rate of drug release, using metoprolol tartrate as the model drug. T he in-vitro drug release was determined using the USP 23 dissolution test a pparatus 5 with slight modification, while the bioadhesive properties were evaluated using texture analyzer equipment with chicken pouch as the model tissue. The incorporation of hydrophilic polymers was found to affect the d rug release as well as enhance the bioadhesiveness. Although high viscosity polymers can enhance the bioadhesiveness of the patches, they also tend to cause non-homogeneous distribution of the polymers and drug, resulting in non-predictable drug-release rates. Of the various bioadhesive polymers stu died, Cekol 700 appeared to be most satisfactory in terms of modifying the drug release and enhancement of the bioadhesive properties. (C) 1999 Elsevi er Science B.V. All rights reserved.