NMR and molecular dynamics studies of tachykinins: Conformation of substance P fragment 4-11

Authors
Coutinho, E Kamath, S Saran, A Srivastava, S
Citation
E. Coutinho et al., NMR and molecular dynamics studies of tachykinins: Conformation of substance P fragment 4-11, J BIO STRUC, 16(3), 1998, pp. 747-755
Citations number
35
Categorie Soggetti
Biochemistry & Biophysics
Journal title
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
ISSN journal
07391102 → ACNP
Volume
16
Issue
3
Year of publication
1998
Pages
747 - 755
Database
ISI
SICI code
0739-1102(199812)16:3<747:NAMDSO>2.0.ZU;2-L
Abstract
The conformation of the C-terminal octapeptide fragment of Substance P (SP4 -11, Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2) has been investigated by 2D-NMR a nd MD methods. The octapeptide exists in a blend of conformations. The mole cule seems to shuttle between conformations with gamma-bends either at Phe5 or Gly6 or Gln3 or Leu7 and between a nearly extended structure.