We report a case of Balo's concentric sclerosis (a variant of multiple scle
rosis) from Papua New Guinea. A 42-year-old woman with a past episode of op
tic neuritis presented with a left hemiparesis. Magnetic resonance imaging
revealed a solitary large tumour-like right cerebral lesion with a pattern
of concentric bands of different signal intensities. The diagnosis was esta
blished by biopsy of the lesion. To our knowledge, this is the first report
ed case of Balo's concentric sclerosis in the indigenous population of Papu
a New Guinea.