The authors describe the case of a severely head injured patient whose prof
ound cerebral infarction was clearly indicated by prolonged desaturation on
jugular venous oximetry, Shortly thereafter jugular venous oxygen saturati
on returned to normal stable values and measured within normal limits for t
he next 24 h, As demonstrated by a computed tomography (CT) scan, these val
ues appear to have represented a jugular mixture of significant amount of c
erebral blood that had passed through infarcted tissue and remained highly
saturated. This is a very graphic example of the misleading influence that
regional flow-metabolic inhomogeneities can have on jugular venous saturati
on and it emphasizes that cerebral ischemia can be easily missed ii no info
rmation on cerebral blood flow or regional metabolism is available.