Quantitative structure-activity relationships of some HIV-protease inhibitors

A quantitative structure-activity relationship (QSAR) study has been made o n different series of cycloalkylpyranones acting as human-immunodeficiency- virus type 1 (HIV-1) protease inhibitors. The results suggest that the enzy me binding affinity of the: compounds would be favoured by a cyclooctyl rin g, a 3-cyclopropylphenylmethyl substituent at the pyranone ring, and a 4-CN -2-pyridine-, an N-Me-imidazole-, or a 3- or 4-CN-phenyl-sulfonamide group at the meta position of the phenyl ring of the 3-substituent.