Preparation of albumin microspheres by an improved process

Albumin is widely used to prepare microspheres and microcapsules. In this s tudy microspheres were prepared by the suspension crosslinking method for t he first time in the absence of any surface active agent, using paraffin oi l as the dispersion medium and formaldehyde as the crosslinking agent. The microspheres thus obtained were characterized using a Scanning Electron Mic roscope and found to be spherical and having a particle size distribution i n the range 50-400 microns. A preliminary drug release study of chlorothiaz ide in-vitro indicated a diffusion controlled release of the drug. This met hod, being simple and cost effective, could be a promising technique for th e large scale manufacture of microspheres.