Asymmetric hydrogenation by an in situ prepared (S)-BINAP-Ru(II) catalyticsystem

Authors
Matteoli, U Beghetto, V Scrivanti, A
Citation
U. Matteoli et al., Asymmetric hydrogenation by an in situ prepared (S)-BINAP-Ru(II) catalyticsystem, J MOL CAT A, 140(2), 1999, pp. 131-137
Citations number
31
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL
ISSN journal
13811169 → ACNP
Volume
140
Issue
2
Year of publication
1999
Pages
131 - 137
Database
ISI
SICI code
1381-1169(19990409)140:2<131:AHBAIS>2.0.ZU;2-4
Abstract
A catalytic system obtained by in situ mixing [RuCl2(benzene)](2) and (S)-B INAP has been tested in the asymmetric hydrogenation of various substrates. The best results have been obtained working in methanol: excellent optical purities were achieved in the reduction of substrates such as tiglic acid (83%), geraniol (97%) and methyl 3-oxobutanoate (95%). Some investigations on the nature of the catalyst have been carried out. (C) 1999 Elsevier Scie nce B.V. All rights reserved.