Substituent and solvent dependent conformations of some saturated diazatricyclic compounds

Authors
Balazs, B Nemes, P Scheiber, P Toth, G
Citation
B. Balazs et al., Substituent and solvent dependent conformations of some saturated diazatricyclic compounds, J MOL STRUC, 475(2-3), 1999, pp. 153-160
Citations number
27
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
JOURNAL OF MOLECULAR STRUCTURE
ISSN journal
00222860 → ACNP
Volume
475
Issue
2-3
Year of publication
1999
Pages
153 - 160
Database
ISI
SICI code
0022-2860(19990202)475:2-3<153:SASDCO>2.0.ZU;2-B
Abstract
The double Mannich condensation of 2-quinolizidone with formaldehyde and me thyl amine resulted in the 11-methyl-7,11-diazatricyclo[7.3.1.0(2,7)]tridec an-13-one of endo-type selectively. The stereochemistry, isomerism and conf ormational behaviour of derivatives obtained by reduction at C-13 were inve stigated extensively by one- and two-dimensional H-1, C-13 and N-15 NMR spe ctroscopy. The site of the protonation and its effect on the conformational equilibria and chemical shifts were also revealed. (C) 1999 Elsevier Scien ce B.V. All rights reserved.