Object. The goal of this study was to analyze the types of failure and long
-term efficacy of third ventriculostomy in children.
Methods. The authors retrospectively analyzed clinical data obtained in 213
children affected by obstructive triventricular hydrocephalus who were tre
ated by third ventriculostomy between 1973 and 1997. There were 120 boys an
d 93 girls. The causes of the hydrocephalus included: aqueductal stenosis i
n 126 cases; toxoplasmosis in 23 cases, pineal, mesencephalic, or rectal tu
mor in 42 cases; and other causes in 22 cases. In 94 cases, the procedure w
as performed using ventriculographic guidance (Group I) and in 119 cases by
using endoscopic guidance (Group II). In 19 cases (12 in Group I and seven
in Group II) failure was related to the surgical technique. Three deaths r
elated to the technique were observed in Group I. For the remaining patient
s, Kaplan-Meier survival analysis showed a functioning third ventriculostom
y rate of 72% at 6 years with a mean follow-up period of 45.5 months (range
4 days-17 years). No significant differences were found during long-term f
ollow up between the two groups. In Group I, a significantly higher failure
rate was seen in children younger than 6 months of age, but this differenc
e was not observed in Group II. Thirty-eight patients required reoperation
(21 in Group I and 17 in Group II) because of persistent or recurrent intra
cranial hypertension. In 29 patients shunt placement was necessary. In nine
patients in whom there was radiologically confirmed obstruction of the sto
ma, the third ventriculostomy was repeated; this was successful in seven ca
ses. Cine phase-contrast (PC) magnetic resonance (MR) imaging studies were
performed in 15 patients in Group I at least 10 years after they had underg
one third ventriculostomy (range 10-17 years, median 14.3 years); this conf
irmed long-term patency of the stoma in all cases.
Conclusions. Third ventriculostomy effectively controls obstructive trivent
ricular hydrocephalus in more than 70% of children and should be preferred
to placement of extracranial cerebrospinal shunts in this group of patients
. When performed using ventriculographic guidance, the technique has a high
er mortality rate and a higher failure rate in children younger than 6 mont
hs of age and is, therefore, no longer preferred. When third ventriculostom
y is performed using endoscopic guidance, the same long-term results are ac
hieved in children younger than 6 months of age as in older children and, t
hus, patient age should no longer be considered as a contraindication to us
ing the technique. Delayed failures are usually secondary to obstruction of
the stoma and often can be managed by repeating the procedure. Midline sag
ittal T-2-weighted MR imaging sequences combined with cine PC MR imaging fl
ow measurements provide a reliable tool for diagnosis of aqueductal stenosi
s and for ascertaining the patency of the stoma during follow-up evaluation
.