We find a Gaussian off-diagonal heat kernel estimate for uniformly elliptic
operators with measurable coefficients acting on regions Omega subset of o
r equal to R-N, where the order 2m of the operator satisfies N < 2m. The es
timate is expressed using certain Riemannian-type metrics, and a geometrica
l result is established allowing conversion of the estimate into terms of t
he usual Riemannian metric on Omega. Work of Barbatis ([1]) is applied to f
ind the best constant in this expression.