Diagnostic value of the PSA subfractions, acid phosphatase and creatine kinase isoenzymes in prostate cancer

Prostate cancer is the second frequent cause of cancer among men. Prostate Specific Antigen ( PSA) is used widely for the diagnosis and during the fol low-up of the patients as well as to distinguish prostatic hyperplasia from prostate cancer. However, PSA values above the reference range may be foun d also in nonmalignant conditions. Conversely, not all prostate cancers giv e rise to an elevated serum PSA concentration, Therefore, new and reliable parameters have been investigated. The ratio of free / total PSA has been f ound to distinguish between prostatic hyperplasia and carcinoma. It has bee n suggested that creatine kinase (CK) and acid phosphatase (ACP) isoenzymes may show significant variation in prostate cancer. In this study, free and total PSA levels and CK and ACP isoenzyme levels were investigated in pati ents with prostate cancer and prostatic hyperplasia, A significant differen ce between the ACP levels was found. Total PSA values were higher in cancer patients. The diagnostic sensitivity and specificity for prostatic cancer was clearly increased by considering the free / total PSA ratio. A higher s pecificitiy was achieved by the combination of the three parameters.