Detection of Doppler signal tends to be more difficult in peripheral veins
owing to low flow velocity. This can be caused by nonoccluding thrombosis,
postthrombotic wall changes, or a deep anatomic location of pelvic veins. T
he last-mentioned frequently is accompanied by interference by bowel gas. i
n addition, inappropriate insonation angles adversely affect the outcome of
color-coded Doppler interrogation. The purpose of the present study was to
evaluate the effectiveness of signal-enhanced color Doppler sonography on
peripheral veins in 31 patients clinically suspected of having deep vein th
rombosis. As a result of diagnostic uncertainty, additional enhanced studie
s were performed on 43 venous segments. The enhancement led to a decrease i
n false-positive results (from four patients to one patient) and false-nega
tive results (from four patients to two patients) compared to unenhanced st
udies. Evaluation of the deeply located pelvic veins profited the most thro
ugh signal enhanced Doppler sonography.