Development of an Epstein-Barr virus type 2 (EBV-2)-associated hepatic B cell non-Hodgkin's lymphoma in an HIV-1-infected patient following a change in the EBV dominant type

Citation
M. Buisson et al., Development of an Epstein-Barr virus type 2 (EBV-2)-associated hepatic B cell non-Hodgkin's lymphoma in an HIV-1-infected patient following a change in the EBV dominant type, LEUKEMIA, 13(2), 1999, pp. 298-301
Citations number
25
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
LEUKEMIA
ISSN journal
08876924 → ACNP
Volume
13
Issue
2
Year of publication
1999
Pages
298 - 301
Database
ISI
SICI code
0887-6924(199902)13:2<298:DOAEVT>2.0.ZU;2-C
Abstract
From the longitudinal study of a cohort of HIV-positive patients, we report the case of a patient who initially harbored the Epstein-Barr virus (EBV) type 1 and subsequently developed an EBV-2-associated non-Hodgkin's B lymph oma a few years after an EBV-2 reactivation, or an exogenous reactivation, in the blood. At the time of diagnosis of hepatic lymphoma, the blood and t he throat harbored high levels of the EBV-1 dominant strain. Sequence analy sis of EBNA-2 gene revealed that: (1) type 2 EBV detected during reactivati on and then in hepatic tumor was very likely to be the same strain and was mostly identical to the EBV prototype AG876; (2) type 1 virus conserved the same mutations during all the follow-up. These results suggest that EBV-2 might be associated with lympho-matogenesis and that a transient reactivati on could lead to the development of an EBV-associated disease.