Synthesis of bistrimethylsilylated hydroxy alkynes

Authors
Bolourtchian, M Zadmard, R Saidi, MR
Citation
M. Bolourtchian et al., Synthesis of bistrimethylsilylated hydroxy alkynes, MONATS CHEM, 130(2), 1999, pp. 333-336
Citations number
10
Categorie Soggetti
Chemistry
Journal title
MONATSHEFTE FUR CHEMIE
ISSN journal
00269247 → ACNP
Volume
130
Issue
2
Year of publication
1999
Pages
333 - 336
Database
ISI
SICI code
0026-9247(199902)130:2<333:SOBHA>2.0.ZU;2-X
Abstract
The syntheses of several bistrimethylsilyl hydroxy alkynes and one tristrim ethylsilyl hydroxy alkyne are described. Addition of lithium trimethylsilyl acetylide to mono- or bistrimethylsilylated aldehydes and ketones afforded compounds 4a-f in good to moderate yields. The products are mixtures of di astereomers; the diastereoselectivity of the reactions amounts to 53 to 68% .