The effect of streptozotocin-diabetes on beta-endorphin level and proopiomelanocortin gene expression in the rat pituitary

Authors
Cheung, CY Tang, F
Citation
Cy. Cheung et F. Tang, The effect of streptozotocin-diabetes on beta-endorphin level and proopiomelanocortin gene expression in the rat pituitary, NEUROSCI L, 261(1-2), 1999, pp. 118-120
Citations number
16
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE LETTERS
ISSN journal
03043940 → ACNP
Volume
261
Issue
1-2
Year of publication
1999
Pages
118 - 120
Database
ISI
SICI code
0304-3940(19990212)261:1-2<118:TEOSOB>2.0.ZU;2-Z
Abstract
Streptozotocin-induced diabetes for 4 weeks resulted in a decrease in proop iomelanocortin (POMC) mRNA in both the anterior lobe (AL) and the neuro-int ermediate robe (NIL) of the rat pituitary. The beta-endorphin levels decrea sed in the NIL but not in the AL. It is concluded that the synthesis of POM C in the pituitary is inhibited in diabetic rats and that there is a decrea se in beta-endorphin release from the anterior pituitary, (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.