Total synthesis of the naturally occurring antibiotic toyocamycin using new and improved synthetic procedures

Authors
Porcari, AR Townsend, LB
Citation
Ar. Porcari et Lb. Townsend, Total synthesis of the naturally occurring antibiotic toyocamycin using new and improved synthetic procedures, NUCLEOS NUC, 18(2), 1999, pp. 153-159
Citations number
12
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
2
Year of publication
1999
Pages
153 - 159
Database
ISI
SICI code
0732-8311(1999)18:2<153:TSOTNO>2.0.ZU;2-X
Abstract
Starting with commercially available tetracyanoethylene, we describe a more efficient and higher yielding synthesis of toyocamycin with regards to con venience, overall yield, and total reaction time than those syntheses previ ously reported.