Kinetics for the acid-catalyzed hydrolysis of purine and cytosine 2 '-deoxy-4 '-thionucleosides

Authors
Elzagheid, MI Oivanen, M Walker, RT Secrist, JA
Citation
Mi. Elzagheid et al., Kinetics for the acid-catalyzed hydrolysis of purine and cytosine 2 '-deoxy-4 '-thionucleosides, NUCLEOS NUC, 18(2), 1999, pp. 181-186
Citations number
21
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
07328311 → ACNP
Volume
18
Issue
2
Year of publication
1999
Pages
181 - 186
Database
ISI
SICI code
0732-8311(1999)18:2<181:KFTAHO>2.0.ZU;2-L
Abstract
Hydrolysis of adenine, guanine and cytosine 2'-deoxy-4'-thionucleosides in aqueous acid has been followed by HPLC. Stability of the compounds and mech anisms of hydrolysis are discussed in comparison with those of the correspo nding native 2'-deoxynucleosides.