Synthesis of a new class of HIV-1 inhibitors

A new family of molecules potentially inhibitors of the HIV-1 Tat-TAR compl ex was prepared. These compounds are constituted by dinucleotide analogs (P NA dimer) bound, through a linker, to an arginine residue. In this series, several molecules inhibit viral development in cell culture with a micromol ar IC50 and without cellular toxicity until 200 mu M concentration.