An index for human lens transparency related to age and lens layer: Comparison between normal volunteers and diabetic patients with still clear lenses

Objective: The light scattering intensity of normal, clear lenses varies wi th age and with the localization within the lens. Realizing the biometry of single lens areas together with their relevant light scattering intensity one should be able to calculate an index to express the lens transparency p roperties of normal human lenses in dependence on age. Performing the same procedure in cases of diabetic patients with still clear lenses it should b ecome possible to obtain an index for the lens transparency properties of l enses under the 'risk factor' diabetes, Methods: 748 eyes with transparent lenses in 383 healthy individuals and 134 eyes with clear lenses in 70 subj ects with diabetes were examined. Scheimpflug slit images of the lens were documented by a Nidek EAS-1000 instrument. Biometry for measuring the dista nce of the single lens layers from the anterior capsule and densitometry fo r determining the light scattering intensity of six defined lens layers alo ng the (theoretical) optical axis were performed. The index of the lens tra nsparency properties was calculated using the tight scattering intensity of a defined lens layer and its distance from the anterior capsule. Results: Lens thickness and light scattering intensities increased linearly with inc reasing age in the normal population as well as in the diabetic patients. T he densitogram pattern of the light scattering intensities in the defined r epresentative six points was similar in both populations, but in the diabet ic group the lens thickness was larger and the light scattering intensities were higher at all ages. Conclusion: The index of lens transparency proper ties calculated with the light scattering intensities of a certain lens are a and its distance from the anterior capsule is a useful measure of lens cl arity in dependence on age. 'Clear' lenses of the diabetic population show significantly higher indices for the lens transparency properties in all ag e groups.