Comparison of clinical and digital assessment of nuclear optical density

To compare the standardised Nidek EAS-1000 densitometric analysis of the le ns with clinical assessment of the nucleus at an early stage of cataract de velopment, 1,200 eyes of 1,204 participants of the VECAT study were assesse d at the baseline using both subjective and objective lens grading. Standar disation of the automatic slit image analysis was achieved using a custom-d esigned EAS-1000 Software version 3.01c. Among 6 measurements of nuclear op tical density, the mean pixel luminescence of integrated anterior nuclear d ensity correlated best with clinical assessment (R = 0.662, p < 0.001). Var iance components that interfere with the assessment are defined.