Influence of anthropometric parameters and biochemical markers of bone metabolism on quantitative ultrasound of bone in the institutionalized elderly

The assessment of bone quality by quantitative ultrasound (QUS), a transpor table and relatively cheap method, shows some correlations with bone minera l density (BMD) as measured by dual-energy X-ray absorptiometry (DXA) and w ith fracture risk. To examine its correlation with bone metabolism in a pop ulation of institutionalized elderly people known to be at high risk for vi tamin D deficiency and secondary hyperparathyroidism, QUS of the calcaneus and biochemical parameters were measured in 264 women aged 85 +/- 7 (SD) ye ars and in 103 men aged 81 +/- 8 years living in 19 nursing homes. Vitamin D deficiency was frequent in this population: 41.9% of the women and 31.4% of the men had a serum 25-hydroxyvitamin (25OHD) level below the 2.5th perc entile level of 3276 normal Swiss adults (6.2 mu g/l or 15.5 mmol/l). Hyper parathyroidism was less frequent: serum parathyroid hormone (PTH) levels we re above the 97.5th percentile level of normal adults (70 pg/l) in 18.9% of women and 9.8% of men. In women, QUS data correlated significantly with ag e (r = -0.297), body mass index (BMI) (r = 0.403), calcium (r = 0.220), PTH (r = -0.296), 25OHD (r = 0.298) and alkaline phosphatase (AP) (r = -0.170) for broadband ultra sound attenuation (BUA), and with age (r = -0.195), BM I (r = 0.208), PTH (r = -0.174), 25OHD (r = 0.140) and AP (r = -0.130) for speed of sound (SOS). In men, ultrasound data correlated with BMI(r = 0.326 ), calcium (r = 0.199), 25OHD (r = 0.258) and AP (r = -0.311) for BUA, and with AP (r = -0.196) for SOS. In women, but not in men because of their sma ller number, a multivariate analysis was performed to examine relationships between age, BMI, biochemical markers and QUS. Age, BMI, PTH and phosphate explained 30% of the variance of BUA and 10% for SOS. In conclusion, QUS o f bone evaluates characteristics of bone that are influenced, at least part ially, by age, BMI and the secondary hyperparathyroidism due to vitamin D d eficiency.