I. Hanssen et al., Field study on the insecticidal efficacy of Advantage against natural infestations of dogs with lice, PARASIT RES, 85(4), 1999, pp. 347-348
A clinical field trial was performed to evaluate the efficacy of imidaclopr
id, the active ingredient of Advantage 10% Spot-On, against natural lice in
festations on dogs. Imidacloprid was highly effective against both sucking
(Linognathus setosus) and biting (Trichodectes canis) lice over the 6-week
period of the trial. The duration of efficacy exceeded the egg-to-image dev
elopment period of both lice. Signs of remission of dermatitis and alopecia
became visible to the pet owners at 2 weeks after treatment. The constant
pruritus caused by the lice was seen for up to 2-4 weeks after treatment ev
en in the absence of lice.