MRI diagnosis of gliomatosis cerebri

Until recently the diagnosis of gliomatosis cerebri has been made on postmo rtem examination, This article reviews the use of serial magnetic resonance imaging studies to suggest premorbid diagnosis of this condition. The foll owing is a case report of a 14-year-old female who had a subtotal cortical resection of tumor and several years later developed a progressive dementia , At postmortem examination the diagnosis of gliomatosis cerebri was made. Diffuse progressive white matter changes involving both hemispheres and bra instem, with increased thickness of the corpus callosum and without changes in cortical markings on T-2-weighted magnetic resonance images, in this pa tient were highly suggestive of the diagnosis of gliomatosis cerebri, (C) 1 999 by Elsevier Science Inc. All rights reserved.