Fatal invasive aspergillosis in an adolescent with cystic fibrosis

We report on a 13-year-old girl with cystic fibrosis (CF) who developed ref ractory airflow obstruction despite high-dose steroids. She developed invas ive aspergillosis and died despite oral and intravenous antifungal therapy. We speculate that the increasing use of immunosuppressive strategies and a ggressive antipseudomonal therapy in CF may lead to an increase in aspergil lus lung disease, including invasive aspergillosis in the future. Pediatr P ulmonol. 1999; 27:130-133, (C) 1999 Wiley-Liss, Inc.