Cytotoxic agent against human gastric carcinoma cells from a kind of Danaidae and its host plant

Authors
Koyama, K Baba, M Watanabe, M Takahashi, H Ishiyama, H Sugimura, T Wakabayashi, K
Citation
K. Koyama et al., Cytotoxic agent against human gastric carcinoma cells from a kind of Danaidae and its host plant, P JPN AC B, 75(1), 1999, pp. 7-9
Citations number
14
Categorie Soggetti
Multidisciplinary
Journal title
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
ISSN journal
03862208 → ACNP
Volume
75
Issue
1
Year of publication
1999
Pages
7 - 9
Database
ISI
SICI code
0386-2208(199901)75:1<7:CAAHGC>2.0.ZU;2-H
Abstract
Cytotoxic activity of chloroform-methanol extracts from 92 kinds of butter flies was tested in vitro against human gastric carcinoma TMK-1 cells. Amon g the species tested, cytotoxicity was found only in a kind of Danaidae, Id eopsis similis, with an IC50 value at the 5 x 1/10(6) dilution. The other b utterflies showed no activity, even at a dilution of 1/10(2). Cytotoxic act ivity was also detected in chloroform-methanol extract from leaves of Tylop hora tanakae, a food source for caterpillars of I. similis. The active prin ciples in I. similis were thus suggested to be derived from compounds prese nt in the leaves of T. tanakae.