Chromosomal clues to the development of prostate tumors

BACKGROUND. Cytogenetic, molecular cytogenetic, and molecular studies of pr ostate cancer have revealed an enormous amount of data regarding chromosoma l loci that are aberrant in prostate tumors. METHODS. These data have been compared and condensed in this review to dete rmine which chromosomes and chromosome sites have been most frequently repo rted. RESULTS. Loss of the Y chromosome, gain of 7, 8, and chi, and interstitial deletions on 6q, 7q, 8p, 10q, 13q, 16q, 17q, and 18q are the most prevalent . CONCLUSIONS. A potential model for genetic control of tumor progression is presented, as are data regarding the evaluation of a new series of tumors. (C) 1999 Wiley-Liss, Inc.