B. Vermeulen et al., Acute appendicitis: Influence of early pain relief on the accuracy of clinical and US findings in the decision to operate - A randomized trial, RADIOLOGY, 210(3), 1999, pp. 639-643
Citations number
19
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
PURPOSE: To determine the influence of early pain relief on the diagnostic
performance of ultrasonography (US) and on the appropriateness of the surgi
cal decision.
MATERIALS AND METHODS: A prospective randomized, double-blind placebo-contr
olled trial with morphine was conducted. A visual analog scale was used to
evaluate pain in 340 patients aged 16 years or older. US was performed with
a standardized protocol. Diagnosis was confirmed at histologic analysis or
, in the patients released without surgery, at follow-up.
RESULTS: One hundred seventy-five patients were injected with morphine, and
165 were injected with the placebo. Pain relief was stronger in the morphi
ne group. In the morphine group, US had lower (71.1%)sensitivity (differenc
e, -9.5%; 95% CI, -18.5%, -0.5%) and higher (65.2%) specificity (difference
, 11.4%; 95% CI, 1.0%, 21.8%). This group had also a higher positive predic
tive value (64.6%) and a lower negative predictive value (71.4%), but the d
ifferences between this group and the placebo group were not statistically
significant. Among female patients, the decision to operate was appropriate
more often in the morphine group (75.8%), but the difference between this
group and the placebo group was not statistically significant (5.1%; 95% CI
, -7.4%, 17.6%). In male patients and overall, opiate analgesia did not inf
luence the appropriateness of the decision. The appropriateness to discharg
e patients without surgery was 100% in all groups.
CONCLUSION: Morphine does not improve US-based diagnosis of appendicitis.