New formulation metered dose inhaler increases breath alcohol levels

A new, chlorofluorocarbon-free metered dose inhaler containing salbutamol, with small amounts of ethanol as a co-solvent, has recently been released. We evaluated the effect on breath alcohol levels of two inhalations from th is metered dose inhaler. In 10 volunteers, breath alcohol levels rose to 17 .9 mu g 100 ml(-1) breath after an inhalation with a good technique, and to 35 mu g 100 ml(-1) breath (the current legal limit for driving in the UK) after a poor inhalation. Breath alcohol levels were reduced by the use of a spacer device, and in all cases fell to near zero after 2 min. In patients who have just used this type of metered dose inhaler, breath alcohol measu rements should be deferred for at least 2 min.