Stereodefined methanephosphonate analogues of nucleic acids

Authors
Citation
La. Wozniak, Stereodefined methanephosphonate analogues of nucleic acids, REV HET CHE, 19, 1999, pp. 173-202
Citations number
120
Categorie Soggetti
Chemistry
Journal title
REVIEWS ON HETEROATOM CHEMISTRY
ISSN journal
09156151 → ACNP
Volume
19
Year of publication
1999
Pages
173 - 202
Database
ISI
SICI code
0915-6151(1999)19:<173:SMAONA>2.0.ZU;2-Y
Abstract
In this review different approaches to the synthesis of stereodefined metha nephosphonate analogues of DNA (Oligo-PMe) are discussed, with special emph asis on the stereoselective methods of preparation of (R-P) dinucleoside (3 ',5')-methanephosphonates, which are building blocks for the preparation of chimeric analogues of DNA. The scope of the use of methanephosphonate anal ogues of DNA as potential therapeutic agents in antisense strategy is brief ly presented in the introduction.