Central nervous involvement in Richter's syndrome.

Introduction. - The authors report a case of neurologic manifestations reve aling Richter's syndrome in chronic lymphocytic leukemia. Exegesis. - Cranial nerve palsies were the initial manifestation of the dis ease. Computed tomography and magnetic resonance imaging were normal. Cereb rospinal fluid analysis with alkaline phosphatase-antialkaline phosphatase revealed the existence of a large-cell lymphoma. Conclusions. - Clinical aspects of this unusual localization of Richter's s yndrome are reviewed. (C) 1999 Elsevier, Paris.