Hemophagocytic syndrome

Citation
Tm. Owaidah et al., Hemophagocytic syndrome, SAUDI MED J, 20(1), 1999, pp. 63-66
Citations number
14
Categorie Soggetti
General & Internal Medicine
Journal title
SAUDI MEDICAL JOURNAL
ISSN journal
03795284 → ACNP
Volume
20
Issue
1
Year of publication
1999
Pages
63 - 66
Database
ISI
SICI code
0379-5284(199901)20:1<63:HS>2.0.ZU;2-8
Abstract
Objectives: Ar King Faisal Specialist Hospital and Research Centre, we retr ospectively reviewed material from II pediatric patients to assess the most common clinical and laboratory features of hemophagocytic syndrome, and to evaluate the outcome of different therapy regimens. Methods: Eleven children with the diagnosis of hemophagocytic syndrome were reviewed. The bone marrow aspiration smears and trephine biopsies were ree xamined under light microscopy to confirm the presence of hemophagocytosis. The different therapeutic agents and patient outcomes are also reviewed. Results: Fever, hepatosplenomegaly and anemia were the most consistent clin ical findings. Bone marrow aspiration and trephine biopsy demonstrated hemo phagocytosis in 9 out of 11 cases. Two patients were diagnosed by lymph nod e biopsy examination and splenic aspirations. Viral infections were documen ted in some cases. Eight patients received specific chemotherapy treatment. Two patients received allogeneic bone marrow transplantation with 12 month s' survival time post-bone marrow transplantation. Conclusion: This review of 11 pediatric patients with hemophagocytic syndro me suggests a familial type rather than an infectious cause. Allogeneic bon e marrow transplantation might be the only curative treatment for hemophago cytic syndrome.