CHLORPROTHIXENE ION-SELECTIVE MEMBRANE ELECTRODES DEVELOPMENT AND APPLICATION IN PHARMACEUTICAL ANALYSIS

The liquid and poly(vinyl chloride) membrane electrodes responsive to the chlorprothixene cation are described. These electrodes are based o n the use of ion-pair complexes of the chlorprothixene picrolonate and chlorprothixene tetraphenylborate. The electrodes exhibit nearly Nems tian response values in different concentration ranges depending on th e used counter ions. The basic analytical parameters of these electrod es were evaluated. The potentiometric titration method was used to det ermine the amount of chlorprothixene hydrochloride in pure form and in tablets with an average of 100,4% and a relative standard deviation o f 1,7%.