T. Nakamura et al., Clinicopathologic variables affecting survival of distal colorectal cancerpatients with macroscopic invasion into the adjacent organs, SURG TODAY, 29(3), 1999, pp. 226-232
A total of 506 distal colorectal cancer patients were classified into two g
roups, to clarify the variables affecting survival of the patients with mac
roscopic invasion into the adjacent organs: 47 cases showed invasion (invas
ive group) while the other did not show invasion (noninvasive group). Diffe
rences between the invasive and noninvasive groups were found in eight vari
ables: female, large tumor size, gross types 3 and 4, moderately or poorly
differentiated adenocarcinomas and signet-ring cell or mutinous carcinomas,
deep cancer invasion, lymphatic invasion, peritoneal and liver metastases,
and curability B-C were found significantly more frequently in the invasiv
e group. The survival curve of the former was significantly (P < 0.05) lone
r than that of the latter. However, no significant difference was found bet
ween the survival curves of the patients with curability A (no residual tum
ors) in both groups. A multivariate analysis in the invasive groups reveale
d six variables to be significantly related to a good prognosis including a
young age, females, a location above the peritoneal reflection, well diffe
rentiated adenocarcinoma, negative lymphatic invasion, and curability A. Su
rgery with curability A should be performed to improve the survival in dist
al colorectal cancer patients with macroscopic invasion into the adjacent o
rgans.