Clinicopathologic variables affecting survival of distal colorectal cancerpatients with macroscopic invasion into the adjacent organs

A total of 506 distal colorectal cancer patients were classified into two g roups, to clarify the variables affecting survival of the patients with mac roscopic invasion into the adjacent organs: 47 cases showed invasion (invas ive group) while the other did not show invasion (noninvasive group). Diffe rences between the invasive and noninvasive groups were found in eight vari ables: female, large tumor size, gross types 3 and 4, moderately or poorly differentiated adenocarcinomas and signet-ring cell or mutinous carcinomas, deep cancer invasion, lymphatic invasion, peritoneal and liver metastases, and curability B-C were found significantly more frequently in the invasiv e group. The survival curve of the former was significantly (P < 0.05) lone r than that of the latter. However, no significant difference was found bet ween the survival curves of the patients with curability A (no residual tum ors) in both groups. A multivariate analysis in the invasive groups reveale d six variables to be significantly related to a good prognosis including a young age, females, a location above the peritoneal reflection, well diffe rentiated adenocarcinoma, negative lymphatic invasion, and curability A. Su rgery with curability A should be performed to improve the survival in dist al colorectal cancer patients with macroscopic invasion into the adjacent o rgans.