Convergent synthesis of the putative biogenetic precursor of mycaperoxide B and a Norsesterterpene triene isolated from an Australian sponge

The synthesis of enantiomerically pure norsesterterpene triene eater 1, ext racted from an Australian marine sponge Latrunculia brevis, has been achiev ed by preparation of E,E-diene 3a via a Julia one-pot olefination and addit ion to 2,5,5,8a-tetramethyl-octahydro-napthalen-1-one 5. The synthesis of Z ,E-diene 3b, the putative biogenetic precursor of mycaperoxide B 2 has also been achieved following the same methodology.