Methylenation and oxidation of chiral non-racemic 2-piperidones: Reactivity of a new 3-oxolactam

Authors
Forns, P Fernandez, MM Diez, A Rubiralta, M Cherrier, MP Bonin, M Quirion, JC
Citation
P. Forns et al., Methylenation and oxidation of chiral non-racemic 2-piperidones: Reactivity of a new 3-oxolactam, SYNTHESIS-S, (2), 1999, pp. 258-263
Citations number
25
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
SYNTHESIS-STUTTGART
ISSN journal
00397881 → ACNP
Issue
2
Year of publication
1999
Pages
258 - 263
Database
ISI
SICI code
0039-7881(199902):2<258:MAOOCN>2.0.ZU;2-P
Abstract
The preparation of (R)-N-(2-hydroxy-1-phenylethyl)-3-methylenepiperidin-2-o ne (2) and (R)-N-(2-hydroxy-1-phenylethyl)piperidine-2,3-dione (3) from the (R)-phenylglycinol-derived lactam 1 is described. We have also studied the reactivity of 3-oxolactam 3, and a series of functionalized derivatives ha s been prepared.