Chiral pyrrolidine derivatives as catalysts in the enantioselective addition of diethylzinc to aldehydes

Authors
Yang, XW Shen, JH Da, CS Wang, R Choi, MCK Yang, LW Wong, KY
Citation
Xw. Yang et al., Chiral pyrrolidine derivatives as catalysts in the enantioselective addition of diethylzinc to aldehydes, TETRAHEDR-A, 10(1), 1999, pp. 133-138
Citations number
39
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
10
Issue
1
Year of publication
1999
Pages
133 - 138
Database
ISI
SICI code
0957-4166(19990115)10:1<133:CPDACI>2.0.ZU;2-C
Abstract
A series of pyrrolidine derivatives with beta-amino alcohol moieties prepar ed from (S)-proline were found to catalyze the enantioselective addition of diethylzinc to aldehydes to yield optically active secondary alcohols with high enantioselectivities. A mechanism accounting for the configurational change with the bulkiness of chiral ligands is proposed. (C) 1999 Elsevier Science Ltd. All rights reserved.