COMPARATIVE-STUDY OF SCE INDUCTION AND CYTOSTATIC EFFECTS BY HOMO-AZASTEROIDAL ESTERS OF N,N-BIS(2-CHLOROETHYL) AMINOBENZOIC ACID IN HUMAN-LYMPHOCYTES

Authors
MOURELATOS D MYLONAKI E PAPAGEORGIOU A BOUTIS L PARADELIS A ANASTASIOU A CATSOULACOS P
Citation
D. Mourelatos et al., COMPARATIVE-STUDY OF SCE INDUCTION AND CYTOSTATIC EFFECTS BY HOMO-AZASTEROIDAL ESTERS OF N,N-BIS(2-CHLOROETHYL) AMINOBENZOIC ACID IN HUMAN-LYMPHOCYTES, Mutation research. Mutation research letters, 346(3), 1995, pp. 129-133
Citations number
12
Journal title
Mutation research. Mutation research letters → ACNP
ISSN journal
01657992
Volume
346
Issue
3
Year of publication
1995
Pages
129 - 133
Database
ISI
SICI code
0165-7992(1995)346:3<129:COSIAC>2.0.ZU;2-V
Abstract
The effect of homo-azasteroidal esters of benzoic acid mustard isomers and the 4-methyl derivatives, which have steroidal lactams as a biolo gical basis, on cytogenetic damage was studied. Twenty compounds were comparatively studied, on a molar basis, as regards their ability to i nduce sister-chromatid exchanges (SCEs) and cell division delays. A co rrelation between potency for SCE induction, effectiveness in cell div ision delay and previously established antitumor activity of these com pounds was observed.